intellimouse explorer 4 scroll wheel not working

Hi
I cant get the scroll wheel to work anywhere in Vista - IE, Office, Explorer, etc etc. I performed an upgrade of my XP SP2 laptop which went ok and am so 80% happy with it. Just a few outstanding issues of which this is one. I had the latest version of Intellisense installed v5.5 before the upgrade and can still run it to customise the mouse functions but if i try to uninstall it with the intent to reinstall it, the error messages are this software is not compatible with this version of windows and a policy restriction prevents the install of this application respectively. I have tried using the application compatibility wizard with no luck and dont know what else to do. There is a windows installer cleanup utility but have held off using this as it was really desinged around the office xp era and so dont want to risk screwing up vista stuff (YET!)
Any ideas would be much appreciated
Regards
Mike